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Lactobacillus acidophilus, 


- a well-documented probiotic strain

LA-5 probiotic strain
4 Min read

Lactobacillus acidophilus, LA-5® (hereafter referred to by the trademark LA-5®) as a probiotic has been described in over 150 scientific publications. More than 60 of these publications describe data originating from clinical trials.


Lactobacillus acidophilus, LA-5® in combination with Bifidobacterium, BB-12® has been associated with promotion of digestive health in numerous studies.

Chr. Hansen Lactobacillus acidophilus, LA-5®

The probiotic strain LA-5® originates from our collection of dairy cultures at Chr. Hansen. It is safe for human consumption; it has been granted QPS1 (Qualified Presumption of Safety) status in Europe. It has been used in food and dietary supplements since 1979.

LA-5® is considered a comprehensively documented probiotic strain as it has been reported in more than 150 scientific publications. More than 60 of these publications reported LA-5® data from clinical trials which had been conducted across numerous areas of health, primarily in combination with Bifidobacterium, BB-12®. These studies predominantly focused on adults and the elderly.

LA-5 scientific and clinical trial publications
LA-5 probiotic strain for the whole family

Gastrointestinal effects

LA-5® in combination with Bifidobacterium, BB-12® may have beneficial gastrointestinal health benefits. Specifically, the combination of these strains has been associated with:


  • Reducing the duration of antibiotic-associated diarrhea.2, 3, 4, 5
  • Reducing the incidence and severity of radiation-induced diarrhea.6
  • Supporting the recolonization of the intestinal microbiota after intake of antibiotics.5, 7  
  • Improvement in irregular bowel movements.8, 9

LA-5® and BB-12® are registered trademarks of Chr. Hansen A/S.

The article is provided for informational purposes regarding probiotics and is not meant to suggest that any substance referenced in the article is intended to diagnose, cure, mitigate, treat, or prevent any disease.
Active lifestyle and LA-5 probiotic strain
Our Chr. Hansen probiotic strains

At Chr. Hansen, our strains are backed by science. All of our probiotic strains are supported by clinical documentation. Learn more about the beneficial effects our strains have on different health areas.


References Open Close

1. EFSA Panel on Biological Hazards (BIOHAZ). Statement on the update of the list of QPS-recommended biological agents intentionally added to food or feed as notified to EFSA 3: Suitability of taxonomic units notified to EFSA until September 2015. EFSA Journal. 2015;13:4331. 
2. Chatterjee S, et al. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated diarrhoea. J Assoc Physicians India. 2013;61(10):708-12. (PubMed)
3. de Vrese M, et al. Probiotic lactobacilli and bifidobacteria in a fermented milk product with added fruit preparation reduce antibiotic associated diarrhea and Helicobacter pylori activity. J Dairy Res. 2011;78(4):396-403. (PubMed)
4. Sheu BS, et al. Pretreatment with Lactobacillus- and Bifidobacterium-containing yogurt can improve the efficacy of quadruple therapy in eradicating residual Helicobacter pylori infection after failed triple therapy. Am J Clin Nutr. 2006;83(4):864-9. (PubMed)
5. Sheu BS, et al. Impact of supplement with Lactobacillus- and Bifidobacterium-containing yogurt on triple therapy for Helicobacter pylori eradication. Aliment Pharmacol Ther. 2002;16(9):1669-75. (PubMed)
6. Linn YH, et al. Effect of Probiotics for the Prevention of Acute Radiation-Induced Diarrhoea Among Cervical Cancer Patients: a Randomized Double-Blind Placebo-Controlled Study. Probiotics Antimicrob Proteins. 2019;11(2):638-47. (PubMed)
7. Nord CE, et al. Oral supplementation with lactic acid-producing bacteria during intake of clindamycin. Clin Microbiol Infect. 1997;3(1):124-32. (PubMed)
8. Shioya M, et al. Effect of fermented milk containing Bifidobacterium lactis FK120 on the fecal flora, with special reference to Bifidum species, and fecal properties in elderly volunteers. Journal of Nutritional Food. 2000:33-4. 
9. Shioya M, et al. Effect of fermented milk containig Bifidobacterium lactis FK120 on the fecal flora and fecal properties in healthy female volunteers. Journal of Nutritional Food. 2000:18.

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