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To better understand the potential health benefits of probiotic bacteria, it is imperative to understand how individual probiotic strains work. Different probiotic strains work in different ways and in different parts of the digestive system. The journey through the digestive system begins when probiotic bacteria enter the mouth (for instance in a probiotic dietary supplement or a yogurt). They must first survive the acidity of the stomach; they then travel through the small intestine where they may support healthy immune function.1-10 They then enter the large intestine where they help support a healthy microbiome, immune function and the gut barrier.1-10
In our labs, we have specialized equipment that enables us to study individual probiotic strains in systems that simulate the human body. By mimicking the human body in these simulated systems, we can learn more about how the different probiotic strains may work to exert their beneficial effects.
The TIM-1 system is an artificial gut system that mimics the stomach and upper small intestine of the human digestive system. It accurately replicates the movement, actions, and environment of the stomach and small intestine. This powerful system helps us understand how probiotic strains can travel and survive through the stomach and upper small intestine. The model is flexible and can be used to simulate different situations, for instance, it can replicate the digestive system of an adult, child or baby. We can set it to simulate what happens after a meal or during a state of fasting. With this system, we can control multiple variables which helps us understand what happens when probiotic bacteria pass through the stomach and small intestine.
The TIM-2 system replicates a portion of the large intestine, also known as the human colon. By using fecal material from test volunteers and study participants, the microbiomes of infants and adults can be studied under different conditions. The TIM-2 system runs its experiments over several days. During this time, what happens to the composition of different bacteria in the microbiome can be studied. The TIM-2 enables us to understand how the microbiome supports human health, increasing our understanding of how the microbiome behaves and functions as a whole.
We also work with human blood collected from blood banks and healthy volunteer donors. Using a very specialized method, we use the blood to study specific parts of the immune system that play an important role when the immune system meets and responds to a challenge. In our labs, we are able to combine a probiotic strain with these specific immune system cells to investigate the potential impact probiotic bacteria have on the immune system.
The lab work we do with these specialized systems allows us to look at how probiotic bacteria work in different life stages and ages and under different conditions in an efficient and non-intrusive manner. This technology allows us to build a greater understanding of how and why probiotic bacteria support different aspects of human health.
TIM-1 and TIM-2 – the TIM company (NL)
The article is provided for informational purposes regarding probiotics and is not meant to suggest that any substance referenced in the article is intended to diagnose, cure, mitigate, treat, or prevent any disease.
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